Miescher granulomatous macrocheilitis: A case report

Miescher granulomatous macrocheilitis (cheilitis granulomatosa) is a mono-symptomatic form of Melkersson-Rosenthal Syndrome (triad of recurrent labial and/or recurrent facial edema, relapsing facial paralysis, and fissured tongue) [1]. The complete classical presentation of Melkersson-Rosenthal syndrome is considered to be rare, occurring in only 25 to 40 percent of cases [2]. The condition was first described by Miescher in 1945 [3]. Orofacial granulomatosis is a unifying terminology showing similar clinical features and a broad spectrum of nonnecrotizing granulomatous inflammation in the oral and facial region [4]. Other entities that need to be considered in the differential diagnosis of orofacial granulomatosis include sarcoidosis, Crohn disease, and infectious disorders (e.g., tuberculosis).